The Molecular Oncology Almanac: Assertion Details

Assertion: Sensitivity to Zelavespib (in Acute Lymphoid Leukemia)
Preclinical

Somatic Variant: JAK1 p.A634D (Missense)

MOHITO JAK1 A634D transplated mice were highly sensitive to growth inhibition by PU-H71.

Citations:

Kucine N, Marubayashi S, Bhagwat N, et al. Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias. Blood. 2015;126(22):2479-83.