The Molecular Oncology Almanac: Assertion Details

Assertion: Sensitivity to Pictilisib (in Invasive Breast Carcinoma)
Preclinical

Somatic Variant: PIK3CA p.C420R (Missense)

In vivo models harboring PIK3CA variants were especially sensitive to GDC-0941.

Citations:

O'Brien C, Wallin JJ, Sampath D, et al. Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models. Clin Cancer Res. 2010;16(14):3670-83.