The Molecular Oncology Almanac: Assertion Details

Assertion: Sensitivity to Olaparib (in Colorectal Adenocarcinoma)
Preclinical

Germline Variant: ATM (Pathogenic)

SK-CO-1 cells are homozygous for ATM c.2251-10>T, lack ATM protein expression, and are sensitive to the PARP inhibitor olaparib.

Citations:

Wang C, Jette N, Moussienko D, Bebb DG, Lees-Miller SP. ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib Translational Oncology. 2017; 10(2):190-196.