Therapeutic Response
CD20 +
status confers therapeutic sensitivity to
Cyclophosphamide
in combination with
Doxorubicin,
Prednisone,
Rituximab, and
Vincristine
in patients with
Burkitt Lymphoma.
Statements
| Source and description |
Rituxan (rituximab) [package insert]. FDA.
The U.S. Food and Drug Administration granted approval to rituximab in combination with chemotherapy for the treatment of pediatric patients aged 6 months and older with previously untreated, advanced state, CD20-positive: diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma (BL), Burkitt-like lymphoma (BLL), or mature B-cell acute leukemia (B-AL). This indication is based on three randomized, active-controlled, open-label, multicenter studies with a collective enrollment of 1854 patients where patients received either CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) or other anthracycline-based chemotherapy regimens.
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