Therapeutic Response Statement (Sensitivity)

This therapeutic response statement Supports the relationship that BRCA2 pathogenic variants status confers therapeutic sensitivity to Abiraterone acetate, Niraparib, Prednisolone in patients with Prostate Adenocarcinoma.

The Republic of Ireland's Health Service Executive (HSE) has approved niraparib in combination with abiraterone acetate and prednisolone for reimbursement as a treatment option for the treatment of adults with metastatic castration resistant prostate cancer (mCRPC) and BRCA1/2 mutations (germline and/or somatic) in whom chemotherapy is not clinically indicated.

This statement is based on a regulatory approval from the Health Service Executive:

Niraparib in combination with abiraterone acetate (Akeega) and predniSONE/prednisoLONE for the treatment of adults with metastatic castration resistant prostate cancer (mCRPC) and BRCA1/2 mutations (germline and/or somatic) in whom chemotherapy is not clinically indicated.

Citation

Niraparib and Abiraterone acetate (Akeega) and prednisoLONE Therapy, 2025, version number 2, NCCP National SACT Regimen, NCCP, viewed 26/03/2026, https://healthservice.hse.ie/documents/6448/848_v2_Niraparib_abiraterone.pdf

Contributions

Date	Contributor	Description
2026-08-02	Van Allen lab	Initial curation of into moalmanac-db
2024-01-16	Van Allen lab	Adding HSE approvals for reimbursement to database
2023-11-01	Health Service Executive	Indication approved for reimbursement.