Therapies

Therapies are the individual cancer treatments referenced by propositions in the database. Each therapy has a therapy type defined by the National Cancer Institute: chemotherapy, hormone therapy, immunotherapy, or targeted therapy. The proposition and statement counts include those where the therapy is given as part of a combination.

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Therapy types
Therapy strategies
Name Therapy strategies Therapy type Propositions Statements
Abemaciclib CDK4/6 inhibition Targeted therapy 19 49
Abiraterone acetate Antiandrogen Hormone therapy 16 26
Adagrasib RAS inhibition Targeted therapy 2 3
Afatinib EGFR inhibition Targeted therapy 2 2
Alectinib ALK inhibition Targeted therapy 1 5
Alpelisib PI3K/AKT/mTOR inhibition Targeted therapy 3 6
Amivantamab EGFR inhibition Targeted therapy 6 18
Anastrozole Aromatase inhibition Hormone therapy 15 27
Arsenic trioxide PML::RARA inhibition Targeted therapy 2 5
Asciminib BCR-ABL inhibition Targeted therapy 2 5
Atezolizumab PD-1/PD-L1 inhibition Immunotherapy 18 21
Aumolertinib EGFR inhibition Targeted therapy 3 3
Avapritinib KIT inhibition Targeted therapy 1 2
Avutometinib MEK inhibition, RAF inhibition Targeted therapy 2 2
Azacitidine Hypomethylating agent chemotherapy Chemotherapy 5 10
Belzutifan HIF-2a inhibition Targeted therapy 3 6
Bevacizumab VEGF inhibition Targeted therapy 27 46
Binimetinib MEK inhibition Targeted therapy 3 12
Blinatumomab CD19 inhibition Immunotherapy 2 9
Bosutinib BCR-ABL inhibition Targeted therapy 1 5
Brentuximab vedotin target CD30 antigens Targeted therapy 6 7
Brigatinib ALK inhibition Targeted therapy 1 3
Camizestrant Estrogen receptor inhibition Targeted therapy 3 3
Capecitabine Thymidylate synthase inhibition Chemotherapy 23 26
Capivasertib PI3K/AKT/mTOR inhibition Targeted therapy 22 29
Capmatinib MET inhibition Targeted therapy 2 4
Carboplatin Platinum-based chemotherapy Chemotherapy 47 73
Cemiplimab PD-1/PD-L1 inhibition Immunotherapy 4 4
Ceritinib ALK inhibition Targeted therapy 1 3
Cetuximab EGFR inhibition Targeted therapy 10 15
Cisplatin Platinum-based chemotherapy Chemotherapy 43 52
Cobimetinib MEK inhibition Targeted therapy 4 6
Corticosteroid Anti-inflammatory Hormone therapy 3 3
Crizotinib ALK inhibition, MET inhibition, ROS1 inhibition Targeted therapy 4 9
Cyclophosphamide Alkylating chemotherapy Chemotherapy 22 49
Cytarabine DNA Polymerase inhibition Chemotherapy 17 21
Dabrafenib B-RAF inhibition Targeted therapy 11 34
Dacarbazine Nonclassical alkylating chemotherapy Chemotherapy 2 2
Dacomitinib EGFR inhibition Targeted therapy 3 3
Dasatinib BCR-ABL inhibition Targeted therapy 3 10
Datopotamab deruxtecan Topoisomerase inhibition, Trop-2 directed antibody Targeted therapy 8 8
Daunorubicin Topoisomerase inhibition Chemotherapy 12 14
Defactinib FAK inhibition Targeted therapy 2 2
Dexamethasone Corticosteroid Chemotherapy 2 3
Docetaxel Taxane-based chemotherapy Chemotherapy 11 34
Dordaviprone Protease activation Targeted therapy 1 1
Dostarlimab PD-1/PD-L1 inhibition Immunotherapy 5 6
Doxorubicin Topoisomerase inhibition Chemotherapy 18 33
Durvalumab PD-1/PD-L1 inhibition Immunotherapy 14 25
Elacestrant ER signaling inhibition Hormone therapy 3 4
Enasidenib IDH2 inhibition Targeted therapy 9 9
Encorafenib B-RAF inhibition Targeted therapy 6 20
Ensartinib ALK inhibition Targeted therapy 1 1
Entrectinib ALK inhibition, NTRK inhibition, ROS1 inhibition Targeted therapy 4 8
Enzalutamide Antiandrogen Hormone therapy 24 24
Epirubicin Topoisomerase inhibition Chemotherapy 4 16
Erdafitinib FGFR inhibition Targeted therapy 6 11
Eribulin Tubulin polymerization inhibition Chemotherapy 1 1
Erlotinib EGFR inhibition Targeted therapy 8 9
Etoposide Topoisomerase inhibition Chemotherapy 4 4
Everolimus PI3K/AKT/mTOR inhibition Targeted therapy 7 10
Exemestane Aromatase inhibition Hormone therapy 6 12
Fludarabine Antimetabolite Chemotherapy 2 2
Fluorouracil Thymidylate synthase inhibition Chemotherapy 35 52
Fulvestrant Estrogen receptor inhibition Hormone therapy 43 78
Futibatinib FGFR inhibition Targeted therapy 3 3
Gefitinib EGFR inhibition Targeted therapy 3 3
Gemcitabine Antimetabolite Chemotherapy 9 13
Gemtuzumab ozogamicin CD33 inhibition Immunotherapy 2 3
Gilteritinib FLT3 inhibition Targeted therapy 8 10
Goserelin Gonadotropin-releasing hormone (GnRH) agonist Hormone therapy 6 12
Ibrutinib BTK inhibition Targeted therapy 1 1
Idarubicin Topoisomerase inhibition Chemotherapy 1 2
Idelalisib PI3K/AKT/mTOR inhibition Targeted therapy 3 3
Imatinib Bcr-Abl inhibition, PDGF-R inhibition, c-Kit inhibition Targeted therapy 11 21
Imlunestrant Estrogen receptor inhibition Targeted therapy 1 2
Inavolisib PI3K/AKT/mTOR inhibition Targeted therapy 3 6
Infigratinib FGFR2 inhibition Targeted therapy 1 1
Inotuzumab ozogamicin BCR-ABL inhibition Targeted therapy 2 5
Ipilimumab CTLA-4 inhibition Immunotherapy 8 28
Irinotecan Topoisomerase I inhibition Chemotherapy 5 6
Ivosidenib IDH1 inhibition Targeted therapy 20 35
Lapatinib HER2 inhibition Targeted therapy 8 10
Larotrectinib NTRK inhibition Targeted therapy 3 6
Lazertinib EGFR inhibition Targeted therapy 2 10
Lenalidomide Angiogenesis inhibition Chemotherapy 2 2
Lenvatinib VEGFR inhibition Targeted therapy 1 1
Letrozole Aromatase inhibition Hormone therapy 16 35
Lorlatinib ALK inhibition Targeted therapy 1 3
Margetuximab HER2 inhibition Hormone therapy 4 4
Methotrexate Antifolate Chemotherapy 4 5
Midostaurin FLT3 inhibition Targeted therapy 10 11
Mirvetuximab soravtansine Folate receptor-alpha inhibition Chemotherapy 3 6
Mitoxantrone Topoisomerase inhibition Chemotherapy 1 1
Mobocertinib EGFR inhibition Targeted therapy 1 1
Nab-paclitaxel Taxane-based chemotherapy Chemotherapy 6 7
Neratinib HER2 inhibition Targeted therapy 8 8
Nilotinib BCR-ABL inhibition Targeted therapy 1 6
Niraparib PARP inhibition Targeted therapy 14 24
Nivolumab PD-1/PD-L1 inhibition Immunotherapy 27 49
Olaparib PARP inhibition Targeted therapy 68 119
Olutasidenib IDH1 inhibition Targeted therapy 5 5
Osimertinib EGFR inhibition Targeted therapy 12 21
Oxaliplatin Platinum-based chemotherapy Chemotherapy 26 30
Paclitaxel Taxane-based chemotherapy Chemotherapy 43 74
Palbociclib CDK4/6 inhibition Targeted therapy 10 25
Panitumumab EGFR inhibition Targeted therapy 5 6
Pembrolizumab PD-1/PD-L1 inhibition Immunotherapy 59 79
Pemetrexed Antifolate Chemotherapy 22 38
Pemigatinib FGFR inhibition Targeted therapy 4 4
Pertuzumab HER2 inhibition Targeted therapy 11 43
Ponatinib BCR-ABL inhibition Targeted therapy 5 8
Pralsetinib RET inhibition Targeted therapy 2 2
Prednisolone Corticosteroid Chemotherapy 10 15
Prednisone Corticosteroid Chemotherapy 14 22
Quizartinib FLT3 inhibition Targeted therapy 3 6
Ramucirumab VEGF/VEGFR inhibition Targeted therapy 3 3
Relatlimab LAG-3 inhibition Immunotherapy 1 1
Repotrectinib ROS inhibition Targeted therapy 4 8
Revumenib Menin inhibition Targeted therapy 5 5
Ribociclib CDK4/6 inhibition Targeted therapy 16 31
Rituximab CD20 inhibition Immunotherapy 15 17
Rucaparib PARP inhibition Targeted therapy 16 16
Sacituzumab govitecan Topoisomerase inhibition Targeted therapy 4 9
Selpercatinib RET inhibition Targeted therapy 6 8
Sevabertinib EGFR inhibition, HER2 inhibition Targeted therapy 1 1
Sotorasib RAS inhibition Targeted therapy 1 2
Sunvozertinib EGFR inhibition, HER2 inhibition Targeted therapy 1 1
Talazoparib PARP inhibition Targeted therapy 27 29
Taletrectinib NTRK inhibition, ROS1 inhibition Targeted therapy 1 1
Tamoxifen Estrogen receptor inhibition Hormone therapy 3 6
Tazemetostat EZH2 inhibition Targeted therapy 7 7
Telisotuzumab Vedotin MET inhibition Targeted therapy 1 1
Tepotinib MET inhibition Targeted therapy 2 4
Tislelizumab PD-1/PD-L1 inhibition Immunotherapy 26 26
Tovorafenib B-RAF inhibition Targeted therapy 4 8
Trametinib MEK inhibition Targeted therapy 11 35
Trastuzumab HER2 inhibition Targeted therapy 38 81
Trastuzumab deruxtecan HER2 inhibition Targeted therapy 14 19
Trastuzumab emtansine HER2 inhibition Targeted therapy 1 4
Tremelimumab CTLA-4 inhibition Immunotherapy 6 12
Tucatinib HER2 inhibition Targeted therapy 2 3
Vandetanib RET inhibition Targeted therapy 1 1
Vemurafenib B-RAF inhibition Targeted therapy 8 11
Venetoclax BCL2 inhibition Targeted therapy 5 5
Vinblastine Vinca alkaloid chemotherapy Targeted therapy 1 1
Vincristine Vinca alkaloid chemotherapy Chemotherapy 10 13
Vinorelbine Vinca alkaloid chemotherapy Chemotherapy 1 1
Vorasidenib IDH1/2 inhibition Targeted therapy 20 40
Zanidatamab ER signaling inhibition Targeted therapy 3 6
Zenocutuzumab NRG1 inhibition Targeted therapy 2 2
Ziftomenib Menin inhibition Targeted therapy 1 1
Zolbetuximab CLDN18.2 inhibition Immunotherapy 2 4
Zongertinib HER2 inhibition Targeted therapy 1 1