BRAF p.V600E

About

Biomarker type: Somatic variant

Gene context: BRAF

HGVS.p: NP_004324.2:p.Val600Glu

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Therapeutic response

Precision oncology relationships for therapeutic response involving this biomarker.

Organizations Biomarkers Cancer types Therapies
FDA (1) BRAF p.V600E Melanoma Atezolizumab, Cobimetinib, Vemurafenib
EMA (2) FDA (2) BRAF p.V600E Melanoma Binimetinib, Encorafenib
EMA (2) FDA (2) BRAF p.V600E Non-Small Cell Lung Cancer Binimetinib, Encorafenib
EMA (2) FDA (2) BRAF p.V600E Colorectal Adenocarcinoma Cetuximab, Encorafenib
EMA (1) FDA (1) BRAF p.V600E Melanoma Cobimetinib, Vemurafenib
EMA (1) FDA (1) BRAF p.V600E Melanoma Dabrafenib
EMA (4) FDA (4) BRAF p.V600E Melanoma Dabrafenib, Trametinib
EMA (2) FDA (2) BRAF p.V600E Non-Small Cell Lung Cancer Dabrafenib, Trametinib
FDA (2) BRAF p.V600E Anaplastic Thyroid Cancer Dabrafenib, Trametinib
FDA (2) BRAF p.V600E Any solid tumor Dabrafenib, Trametinib
EMA (1) FDA (2) BRAF p.V600E Low-Grade Glioma, NOS Dabrafenib, Trametinib
EMA (1) FDA (1) BRAF p.V600E Melanoma Trametinib
EMA (1) FDA (1) BRAF p.V600E Melanoma Vemurafenib
FDA (1) BRAF p.V600E Non-Langerhans Cell Histiocytosis/Erdheim-Chester Disease Vemurafenib
EMA (1) FDA (1) BRAF p.V600E Low-Grade Glioma, NOS Tovorafenib
EMA (2) FDA (1) BRAF p.V600E Colorectal Adenocarcinoma Cetuximab, Encorafenib, Fluorouracil, Oxaliplatin
EMA (1) BRAF p.V600E High-Grade Glioma, NOS Dabrafenib, Trametinib
FDA (1) BRAF p.V600E Colorectal Adenocarcinoma Cetuximab, Encorafenib, Fluorouracil, Irinotecan
EMA (1) BRAF p.V600E Differentiated Thyroid Gland Carcinoma Dabrafenib, Trametinib