BRCA1 pathogenic variants

About

Biomarker type: Germline variant

Gene context: BRCA1

Chromosome: 17

Requires pathogenic: True

Mappings
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Therapeutic response

Precision oncology relationships for therapeutic response involving this biomarker.

Organizations Biomarkers Cancer types Therapies
EMA (1) FDA (1) BRCA1 pathogenic variants Prostate Adenocarcinoma Abiraterone acetate, Niraparib, Prednisone
FDA (1) BRCA1 pathogenic variants Ovarian Epithelial Tumor Niraparib
FDA (1) BRCA1 pathogenic variants High-Grade Serous Fallopian Tube Cancer Niraparib
FDA (1) BRCA1 pathogenic variants Peritoneal Serous Carcinoma Niraparib
EMA (1) FDA (2) BRCA1 pathogenic variants Ovarian Epithelial Tumor Olaparib
EMA (1) FDA (2) BRCA1 pathogenic variants High-Grade Serous Fallopian Tube Cancer Olaparib
EMA (1) FDA (2) BRCA1 pathogenic variants Peritoneal Serous Carcinoma Olaparib
EMA (1) FDA (1) BRCA1 pathogenic variants Ovarian Epithelial Tumor Bevacizumab, Olaparib
EMA (1) FDA (1) BRCA1 pathogenic variants High-Grade Serous Fallopian Tube Cancer Bevacizumab, Olaparib
EMA (1) FDA (1) BRCA1 pathogenic variants Peritoneal Serous Carcinoma Bevacizumab, Olaparib
EMA (2) FDA (2) BRCA1 pathogenic variants, HER2-negative Invasive Breast Carcinoma Olaparib
EMA (1) FDA (1) BRCA1 pathogenic variants Pancreatic Adenocarcinoma Olaparib
EMA (1) FDA (1) BRCA1 pathogenic variants Prostate Adenocarcinoma Olaparib
FDA (1) BRCA1 pathogenic variants Prostate Adenocarcinoma Abiraterone acetate, Olaparib, Prednisolone
FDA (1) BRCA1 pathogenic variants Prostate Adenocarcinoma Abiraterone acetate, Olaparib, Prednisone
FDA (1) BRCA1 pathogenic variants Ovarian Epithelial Tumor Rucaparib
FDA (1) BRCA1 pathogenic variants High-Grade Serous Fallopian Tube Cancer Rucaparib
FDA (1) BRCA1 pathogenic variants Peritoneal Serous Carcinoma Rucaparib
FDA (1) BRCA1 pathogenic variants Prostate Adenocarcinoma Rucaparib
EMA (1) FDA (1) BRCA1 pathogenic variants, HER2-negative Invasive Breast Carcinoma Talazoparib
FDA (1) BRCA1 pathogenic variants Prostate Adenocarcinoma Enzalutamide, Talazoparib
EMA (2) BRCA1 pathogenic variants Prostate Adenocarcinoma Abiraterone acetate, Niraparib, Prednisolone