AKT1
About
Location: 14q32.33
Mappings
Biomarkers
AKT1 is involved in the following curated biomarkers.
| Name | Biomarker type | Propositions | Statements |
|---|---|---|---|
| AKT1 amplification | Copy number | 3 | 4 |
| AKT1 oncogenic variants | Somatic variant | 3 | 4 |
Therapeutic response
Precision oncology relationships for therapeutic response involving this gene.
Organizations
Biomarkers
Cancer types
Therapies
| Organizations | Biomarkers | Cancer types | Therapies | |
|---|---|---|---|---|
| EMA (1) FDA (2) | AKT1 oncogenic variants, ER positive, HER2-negative | Invasive Breast Carcinoma | Capivasertib, Fulvestrant | |
| FDA (2) | AKT1 oncogenic variants, HER2-negative, PR positive | Invasive Breast Carcinoma | Capivasertib, Fulvestrant | |
| FDA (2) | AKT1 oncogenic variants, ER positive, HER2-negative, PR positive | Invasive Breast Carcinoma | Capivasertib, Fulvestrant | |
| EMA (1) FDA (2) | AKT1 amplification, ER positive, HER2-negative | Invasive Breast Carcinoma | Capivasertib, Fulvestrant | |
| FDA (2) | AKT1 amplification, HER2-negative, PR positive | Invasive Breast Carcinoma | Capivasertib, Fulvestrant | |
| FDA (2) | AKT1 amplification, ER positive, HER2-negative, PR positive | Invasive Breast Carcinoma | Capivasertib, Fulvestrant |