ABL1

About

Location: 9q34.12

Mappings

HGNC: HGNC:76

Ensembl: ENSG00000097007

NCBI: 25

Refseq: NM_005157.6

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Biomarkers

ABL1 is involved in the following curated biomarkers.

Name	Biomarker type	Propositions	Statements
BCR::ABL1	Gene fusion	25	62
ABL1 p.T315I	Somatic variant	4	7

Therapeutic response

Precision oncology relationships for therapeutic response involving this gene.

Organizations	Biomarkers	Cancer types	Therapies
FDA (2)	BCR::ABL1	Chronic Myelogenous Leukemia	Asciminib
EMA (1) FDA (1)	ABL1 p.T315I, BCR::ABL1	Chronic Myelogenous Leukemia	Asciminib
EMA (5) FDA (1)	CD19 +, not BCR::ABL1	Acute Lymphoid Leukemia	Blinatumomab
EMA (3) FDA (2)	BCR::ABL1	Chronic Myelogenous Leukemia	Bosutinib
FDA (3)	BCR::ABL1	Chronic Myelogenous Leukemia	Dasatinib
FDA (3)	BCR::ABL1	Chronic Myeloid Leukemia, BCR-ABL1+	Dasatinib
FDA (2)	BCR::ABL1	Acute Lymphoid Leukemia	Dasatinib
FDA (2)	BCR::ABL1	Chronic Myelogenous Leukemia	Imatinib
EMA (2) FDA (2)	BCR::ABL1	Chronic Myeloid Leukemia, BCR-ABL1+	Imatinib
FDA (2)	BCR::ABL1	Acute Lymphoid Leukemia	Imatinib
FDA (3)	BCR::ABL1	Chronic Myelogenous Leukemia	Nilotinib
FDA (3)	BCR::ABL1	Chronic Myeloid Leukemia, BCR-ABL1+	Nilotinib
EMA (1) FDA (1)	BCR::ABL1	Acute Lymphoid Leukemia	Cytarabine, Dexamethasone, Methotrexate, Ponatinib, Prednisone, Vincristine
FDA (1)	ABL1 p.T315I, BCR::ABL1	Acute Lymphoid Leukemia	Ponatinib
EMA (2) FDA (1)	ABL1 p.T315I	Chronic Myelogenous Leukemia	Ponatinib
FDA (2)	BCR::ABL1	Chronic Myeloid Leukemia, BCR-ABL1+	Asciminib
EMA (2)	CD22 +, not BCR::ABL1	Acute Lymphoid Leukemia	Inotuzumab ozogamicin
EMA (3)	BCR::ABL1	Chronic Myeloid Leukemia, BCR-ABL1+	Bosutinib
EMA (2)	not BCR::ABL1	Chronic Myelogenous Leukemia	Imatinib
EMA (2)	not BCR::ABL1	Acute Lymphoid Leukemia	Imatinib
EMA (1)	not BCR::ABL1	Acute Lymphoid Leukemia	Ponatinib
EMA (1)	ABL1 p.T315I, not BCR::ABL1	Acute Lymphoid Leukemia	Ponatinib
EMA (1)	not BCR::ABL1	Chronic Myelogenous Leukemia	Asciminib
EMA (3)	not BCR::ABL1	Chronic Myelogenous Leukemia	Dasatinib
EMA (2)	not BCR::ABL1	Acute Lymphoid Leukemia	Dasatinib
EMA (3)	not BCR::ABL1	Chronic Myelogenous Leukemia	Nilotinib