ABL1 p.T315I

Biomarker type: Somatic variant

Gene context: ABL1

HGVS.p: NP_005148.2:p.Thr315Ile

Precision oncology relationships for therapeutic response involving this biomarker.

Organizations

Biomarkers

Cancer types

Therapies

Organizations	Biomarkers	Cancer types	Therapies
EMA (1) FDA (2)	ABL1 p.T315I, BCR::ABL1	Chronic Myeloid Leukemia, BCR-ABL1+	Asciminib
FDA (2)	ABL1 p.T315I, BCR::ABL1	Acute Lymphoblastic Leukemia	Ponatinib
EMA (2) FDA (2)	ABL1 p.T315I, BCR::ABL1	Chronic Myeloid Leukemia, BCR-ABL1+	Ponatinib
EMA (1)	ABL1 p.T315I, not BCR::ABL1	Acute Lymphoblastic Leukemia	Ponatinib